chances of chemical pregnancy with pgs normal embryo

I suspected that my Hashimotos had something to do with the chemicals so we figured we will do IVF#4 and PGS test the embryos. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. PGS testing done this round 8 high quality normal embryos. First, PGS improves pregnancy rates. I feel like most times the protocol for autoimmune issues is the same. Consult with your doctor before making any treatment changes. A chemical pregnancy is a very early miscarriage that happens within the first five weeks of pregnancy. Was just curious if the percentages of a live birth increase after a positive pregnancy test. These studies were particularly small so drawing conclusions isnt really possible yet. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? (2017)found a reduction in embryo survival (from 98% to 93%) and a reduction inlive birth rate(50% to 27%). Once I started hearing other people's stories I was shocked at how common it is- more so than I ever would have imagined. There are many potential causes of an . Or is it worth having the actual tests done? No clinic ended up quoting more than 60-70% . When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. Has anyone had this happen and did any further testing determine the cause? I had a chemical pregnancy last November after a fresh transfer. I have to say that I'm not 100% sure I needed any of the extra things we did- but I wanted to try whatever I could and these things couldn't hurt. We were told not to worry and try again after a month, and in March I found I was pregnant again but this turned out to be a chemical pregnancy. I took the year off to just work on myself and be in a better mental state. I know how devastating loss can be but theres always, always hope. Check out mycomplete guide to embryo grading and success ratesto learn more about embryo development, grading and success rates. I've already previously had 2 hysteroscapies (previously had a uterine septum - one hysteroscapy removed it, the other confirmed there was no scar tissue left). We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! My first FET was a day 6 5AA euploid embryo. However we now understand that the chromosomes are only part of the issue. Statistically speaking it takes an average of two transfers before a successful pregnancy. (2021) in their retrospective multicenter study compared the transfer of 1000 mosaic embryos and over 5500 euploid embryos between 2015 and 2020. Then my 3rd transfer and 2nd FET is now my baby boy growing well at 16 weeks 4 days. I just officially confirmed another Chemical pregnancy for me. Best of luck to you. It will involved thawing your embryos, biopsying, then re-freezing and ultimately re-thawing if the embryo is euploid and you want to transfer it. But what about the women who didnt get blasts? Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done. The RE I ended up with said "lets fight for this!" Congratulations on your success , I have a similar story. I did acupuncture that cycle. Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. This is all so hard and stressful. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. Did your RE have you take anything other than progesterone and estrogen and aspirin? In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. Will be put on lovenox this round as well. This test can identify chromosomally normal embryos, which increase the chances of a healthy pregnancy. Did you carry to full term? However, that information will still be included in details such as numbers of replies. Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. After each failed transfer, my RE did a lot of additional testing including a Yale EFT biopsy for receptivity and a clotting test to see if I needed lovenox and/or baby aspirin. Im sorry to hear of your loss! If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Multiple losses due to chromosomal abnormality, did you do ivf? Thanks again! All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. Interestingly enough my protocol remained the same between my chemical FET and the successful one. But if you dont like the extra meds you could talk with your current or new clinic about not doing it and get their thoughts on it. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. Does it still matter? Mosaics are embryos that have a mix of euploid and aneuploid cells. Another thing to consider: Has your doctor done a hysteroscopy? I actually didnt have embryos to bring with me when we switched. Out of the 6 that were pgs tested, 3 came back normal and 1 came back inconclusive. Please don't give up! I guess this probably qualifies me as a poor responder which obviously doesn't feel good after all the other issues we've had. Single embryo transfer both times. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. I haven't done the transfer yet due to various reasons, and even though nothing is guaranteed, I like going into it knowing that I have a better chance because it is a normal embryo. For more background info, check out my post onPGS Testing. I refused to go into another FET without doing some test or adjusting 1 variable, otherwise it was just repeating the same mistakes in my mind. Dogpark in reply to Mogwai_2 3 years ago. is there another clinic in your area you can switch to? (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. thats a great suggestion! Thanks! It took me 3 fresh + 3 frozen but I finally did get my baby. Check here for the full glossary (please excuse the repeated terms!). Genetic testing was normal. 4 PGT-M and PGT-A vs. Prenatal Testing A pregnancy that doesn't even make it to the 6 week scan where they can usually see the fetus on an ultrasound. Reply Share React operationpepper Dec 22, 2015 3:42 PM Another small study found no difference in survival or live birth rates with rebiopsied embryos (Cimadomo et al. The majority of these studies used double embryo transfers, either when transferring euploid embryos, in the control untested groups, or both. Then another IVF/ICSI but nothing to transfer-- my doctor switched up my meds which was a bad idea obviously. If you have any questions about my protocol happy to answer. Took 2 years of "fighting" but looking back all the money, pain. And I can't say thats the sole reason this one stuck, but it is the one thing we did differently, and here I am. I think whats missing is the success rates for transfers of non PGS tested embryos. (2021) in their multicenter prospective trial transferred 484 euploid, 282 low mosaic (where 20-30% of the cells are aneuploid) and 131 moderate mosaic (30-50%) embryos. By screening out abnormal embryos with PGS, physicians can transfer just one chromosomally normal embryo, increasing the chances for having a successful singleton pregnancy and healthy child. I have had MENTS one BFN and one chemical on untested embryos on my first round of IVF (I'm 34). Women above 35 seem to benefit the most with PGS . Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. So sorry this happened and good luck to you. Im sure that data exists especially since thats how things used to be done back in the day. Have you ever had an endometrial biopsy to look for infection? I am new to the online support groups and considered joining months ago but struggled to even bring myself to put my story out there. After my negative, we did ERA and had a hysteroscopy to correct a small septum. To perform the biopsy, an embryologist removes 2-10 cells from the precursor placenta cells of the blastocyst embryo, called the trophectoderm. In a small study,Bradley et al. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. I feel so lucky that I found this community. I had also changed from an estradiol tablet to estradiol patches in my first FET. Trade-offs of PGT-A (or PGS) So all the aneuploid embryos that were transferred either didnt implant, or miscarried. For more up-to-date information on this topic check out my other posts that are tagged withEmbryo rebiopsy. Have you been tested for APS (antiphosolipid syndrome)? Ive done 4 transfers now with PGS tested embryos - the first failed and the last 3 resulted in chemical pregnancies. Theper retrievalstatistic helps to see the chancesbefore PGStesting. Low mosaics had a miscarriage rate of 11.0%, None of these were statistically significant from the other (, Euploid embryos had an 8.6% miscarriage rate, All of the mosaics had a 20.4% miscarriage rate, <50% mosaic segmental embryos had a 13.6% chance of miscarriage, >50% mosaic segmental embryos had a 20.3% chance of miscarriage, <50% two whole chromosome mosaics had a 11.9% chance of miscarriage, <50% complex (>2 whole chromosomes) mosaics had a 26.7% chance of miscarriage, >50% two whole chromosome mosaics had a 39.9% chance of miscarriage, >50% complex (>2 whole chromosomes) mosaics had a 44.3% chance of miscarriage. 1st IVF Cycle with initial low beta results, Day 6 Blastocysts / PGS / embryo "Hunger Games". My current success was a FET with NO meds except vaginal progesterone. For <37, this was about 5, for 37-40 about 4, and for >40 about 3 (so older women tend to produce fewerblasts). PGS enhances the success of IVF but not in all cases; the success rates vary by age. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. I have however done Intralipid Infusions and taken Neupogen beginning a week before transfer for Autoimmune protocol (although Ive never actually been tested for Autoimmune disorder). Hello. I will ask my dr about this. Thanks in advance! Ive never had one. We transferred our only day 6/PGS tested Euploid embryo on December 10,2020. Disclaimer: Any studies presented here may be contradicted by other studies. And congratulations on your pregnancy!! I did PGS testing. Terms are highlighted every 3rd time to avoid repetition. Its very disheartening though. Starting in the late 1990s, doctors testing fertilized eggs classified them as normal or abnormal, then added the classification "mosaic" in 2015. Did anyone else have success after failure with PGS? About 7 months later I transferred a day 7. 2nd was an FET that was a chemical, likely due to an embryo issue, even though it was graded highest. Nov 2016-IVF #2 16 eggs -> 3 PGS-normal embryos Jan 2017-single FET #2: BFN . I have considered going to Braverman in NYC but I think that Kofinas tested me for everything Braverman tests for. I wanted to reach out and see if you know a way to find a surrogate on your own, rather than going thru an agency. The embryo biopsy can be utilized to perform preimplantation genetic screening or PGS. My RE had said shes usually very cautious when it comes to sending embryos out for PGS testing only because the process can sometimes compromise the embryo itself. 1) Has anyone else had the immune suppressing protocol NOT work, and then gone on to have it work? Note that this paper is still preprint as of Nov 2021. It worked and now Im 24 weeks pregnant with twins! After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. I also am interested in doing an endo scratch beforehand and adding Viagra if the shots and scratch aren't doing the job. My doctor is recommending a Receptiva test to uncover any other reasons why the pregnancies won't last. Im sorry for your loss My first was also a frozen transfer and I agree, there is more prep involved. It was a chemical pregnancy. For women who have it, REs may suggest prednisone and lovenox after transfer. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. There is much better chance of IVF success with PGS testing in women who were over the age of 35. Wondering if anyones had a similar experience or has any advice. The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband. My current doctor reviewed my history and suggested an endometrial biopsy for endometritis (different from endometriosis). I got my period or should I say we officially begun to miscarry on Saturday so I did call them with our Day 1. We put back a normal PGS tested embryo. If youre confused about the terminology youll see coming up, check my post on understanding PGS testing results. I think it would be worth it to do a endometrial receptivity analysis to test your implantation window. Every positive thing helps! They found a reduction in live birth rates (50% to 39%), although this was notstatistically significant(it was from a small study). PGT-A is able to evaluate the % of cells that are abnormal in a biopsy sample and if theres a mix of euploid and aneuploid cells then the embryo is a mosaic. She is pregnant right now from that cycle. Meaning that if you begin a cycle, retrieve eggs, produce embryos, then do PGS testing, and at least one embryo comes back normal, 60 - 70% of the time it will lead to a live birth. Causes of a chemical pregnancy. According to the geneticist, there is as much chance it could be completely normal as the chance that it is abnormal. Wishing you the best of luck and baby dust. It wouldnt be going far at least. definitely worth asking! END MENT And the fact that the embryo's are at least starting to implant is confusing me in relation to my lining - Does that mean that my thinner lining is OK? We were hoping for a Christmas miracle however that was short lived. Aww happy your second round worked! History I remember you from another post I made about only having 2 eggs fertilized you were so kind to share your story. Does PGT-A reduce the chances of miscarriage? Oops, meant to say Im 17 weeks pregnant from my last FET! Hi everyone. Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. Comprehensive Chromosome Screening (CCS) is one technique of PGT-A that can identify whether an embryo is XX (female) or XY (male). It looks like at this time that it's implantation failure rather than abnormal embryos, since we got a good one from the ones we had tested. Im still taking it! I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. It sucks cause I only have one shot left at this and Im already against odds cause its a day 7 embryo , So RE doesnt think i need ERA because I did get pregnant. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. Seems to work for many, many women. END MENTS We really expected to find success with our first pgs transfer even though our company and RE only quoted 60% odds per embryo transferits a good but tough reminder that its not expected to always work. Thought this was tested out, but apparently that can't be detected by the PGT test. Good luck and feel free to PM me. She said that this is something that is prevalent in recurrent pregnancy loss and failed implantations. Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. Women over 35 were not shown to have increased pregnancy rates from PGT unless they made many embryos that needed evaluation. I know Im my heart I want to try again, but my brain is working overtime too - odds, finances, and the risk of suffering all over again, Im so sorry to hear all this! More high quality studies need to be performed to really see the answer to this question. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. But I do have a friend who had 1 embryo shipped from Utah to California for an FET and it was a different clinic that handled the FET. Obviously this is not an ideal situation but sometimes this happens. He suggested an endometrial biopsy instead. For these groups, about 50% of biopsies had noeuploidembryos. 2 came back normal. END MENTS. That embryo implanted but resulted in a chemical pregnancy. Alternatively you can check out my websites tag for mosaic embryos here. Thats definitely worth looking into, thanks for sharing your experience! I felt like a number in his practice, and I think he was milking my insurance for all he could get. I was put on the Schoyer protocol for stimulation. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. This is my second failure of a PGS tested embryo, and the first on this immune suppressing protocol. I have one more embryo remaining. Terms are highlighted every 3rd time to avoid repetition. They may be able to use the same sample as the ERA if you do both. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. I can't tell if that is from the progesterone. Sorry to hear about your recent cycle. Nov 2, 2016 8:12 AM. (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). (I had these done at a private lab since my nurse wouldn't let me come in early) My last donor embryo cycle was also a chemical pregnancy but no PGS was done. no, I just took those 3. Hi, sorry about your 1st FET chemical. Im so confused as my RE says that morphology doesnt matter if theyre euploid. My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). Autoimmune Testing? Would you ladies push next time for a different protocol? Can any further conclusion be made based on number of normal pgs results ? (2016)looked at over 18,000 Day 5 embryo biopsies (usingthe older SNP technology) and reported the chances of an embryo beingeuploid(based on age): So up until 37 theres about a 50% chance of each blastocyst being a euploid, this cuts in half to about 25% at 42. Going into my second round of IVF I was doubting anything would work. If you have not I would suggest an embryo scratch/biopsy before your next FET. I had another hysteroscopy after my chemical but b/c it had been nearly 2 years since I had one when i started IVF. I had a PGT normal day 7 embryo that unfortunately resulted in a chemical. My first FET with my only normal embryo was successful but ended at 7.5 weeks with a MMC The devastation was unreal. This can be done! For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. , Ive done embryo glue every transfer but no luck unfortunately :(. Thanks for sharing your story because it does give me hope! He was surprised my doctor was doing a Receptiva test naturally, without medication, since the idea is to simulate the same environment of a transfer, and was also surprised that my doctor had done a 5-day-post-retrieval-transfer in the first place. After the first, we did the era and added the endo scratch. Check mycomplete guide to mosaic embryosto learn more about mosaics, or mycomplete guide to PGT-Ato get more background on PGT-A (akaPGStesting). I only have embryo left ugh . Gearing up for FET Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). I plan on asking my RE for a Recurrent loss panel to be done and autoimmune testing (NK cells etc)and a different protocol. However, this study did not focus on the >35 age group, which is likely to be the most benefited by this technique. We timed everything to my cycle. And my RE is kind of resistant to doing extra tests before I have a second failure, which I find a little crazy. Good luck and dont give up on hope yet! Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Learn more about, Learn About What to Expect's Pregnancy & Baby App. My first fresh transfer ended in miscarriage due to low progesterone, I was on supplements but not enough. According to the authors, the >35 group analysis should be interpreted with caution as the sample size was small. We had PGS/PGD testing and an ERA. I would Love and Need your opinions on this. Some of the reasons quoted werent even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, theres a margin of error with the testing itself, pgs doesnt tell us everything about an embryo, etc. I didnt realize you could transfer your embryos to another clinic. My husband and I started trying to get pregnant about a year ago (we're both 35). also did you have to do another stim cycle? 5AB euploid embryo. Just thought Id throw this test out there though! We strive to provide you with a high quality community experience. 2005-2023Everyday Health, Inc., a Ziff Davis company. I am 42. Chemical pregnancy with PGS tested embryo. Dr is responsible for allowing . Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. This educational content is not medical or diagnostic advice. I'm curious if this might have something to do with it. I ended up taking Lovenox and Prednisone and doing an endometrial scratch biopsy and ERA. Then for my second FET we did an unmedicated FET and it worked. As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). thanks for sharing! This was something that almost all of our embryos had problems with (a high drop off rate of embryos growing in the lab and all were always low rated if they made it to blastocyst stage). Success rates for graded euploids are given here https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates. A genetically normal embryo has a 70% chance of a positive pregnancy test in any woman, whether she is 20 years old or 40 years old. , dont be sorry! (2016)found nostatistically significantdifference inongoing pregnanciesbetween Day 5 and 6 euploids (78.6% vs 67.4%), but this was reduced by Day 7 (43.8%). I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. They biopsied those 2 embryos and send off the cells for PGS testing. Recurrent Chemical Pregnancy - PGS embryo (and Donor egg ) Advice needed. Terms are highlighted every 3rd time to avoid repetition. Existing data show that the live birth rate is between 60-80% when a single frozen embryo is transferred in a second cycle. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. Some are faster, and some are slower. I am so frustrated, disappointed, hurt, sad and angry right now. Not exactly! I hope this helps. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Mosaic embryos can be either low- or high . My 2nd also failed and I had them do a thrombophilia panel on me and found I had a MTHFR mutation so we added folgard and he adjusted my days on progesterone and in addition to the suppositories I did the shots as well. I cried the whole way home. Im willing to try anything :) thanks for sharing! Reply Share React AMB425 Sep 2, 2016 11:01 AM Besides that, there are no gaurantees of both sticking. My AMH was low, around 1.5, FSH was slightly high, and follicle count was low normal. Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. I am not naive I know bad things can happen. Is it because they were early blastocysts? I think its valuable information because many people dont realize the chances of not getting blasts/eligible blasts for biopsy. I had been on birth control since I was 18 and had no idea what to expect when I came off it. The good thing is she did not see any scar tissue during the biopsy, and the inflammation had completely cleared up. Another study agrees with these data (Franasiak et al. For the autoimmune stuff above I was tested by Alexander Kofinas. I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. Second, PGS speeds up the time to pregnancy. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Im going to talk to my dr about getting this test done. amazing, that gives me hope :) thanks so much! Go figure, right?! My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. I dont see myself spending a fortune on acupuncture again. Im currently 17 weeks from another FET. The chart below, based on information published in Reproductive Biomedicine Online, in 2016, shows:. MENTS We were devastated after our first pgs transfer ended in a chemical, and unfortunately we went on to have one more before finding success. - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. Im still u sure if this will go to term, but getting a 2nd opinion from a specialist in RPL sure has made a difference. I an 33 and my husband is 37. Consult with your doctor before making any treatment changes. thank you for sharing! Does this harm the embryo or reduce its potential for success? Find advice, support and good company (and some stuff just for fun). 5AB euploid embryo. Is there any reasoning behind this- is it due to poor egg quality, poor sperm quality, or both? Im surprised there are still doctors out there who do not bring up this protocol. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. I just wish we had more answers so we can prepare for the next .
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